Human Coronary Artery Lesions:

Atherothrombotic is a systemic disease of the coronary vessel wall that causes coronary artery lesions appearing heterogeneous in morphology and chemical constitution. Disrupting or vulnerable plaques in the coronary arteries exhibit a thin fibrous cap (fibrous cap thickness 65 to 150 μm) with a large lipid core, as defined by American Heart Association AHA plaque type V-Va [1]. Acute coronary syndromes often result from disruption of a modestly steno tic vulnerable plaque. Coronary artery vulnerable plaques occasionally show high likelihood of thrombotic complications and rapid progression of lipid content and a thin fibrous cap [2]. Coronary arteries are thin but their measurements speculate important clinical correlates [3]. Quantitation of the high-risk plaque lipid components and degree of stenosis is state-of-art approach but difficult [4].